Lactobacillus reuteri
Lactobacillus reuteri DSM 17648
Pylopass (DSM 17648)
Binding to Helicobacter pylori to help clear it from the stomach lining.
Quick Overview
At a Glance
Researched Benefits
- Clinically shown to boost H. pylori eradication rates when used alongside standard antibiotic therapy
- Helps soothe digestive discomfort — less bloating, stomach pain, and constipation during treatment
- Works as a postbiotic, so it is heat-stable and does not require refrigeration in most formulations
- May help address H. pylori-related bad breath from the inside out
Usage & Application
Clinically Studied Dosage
200 mg (approximately 200 billion heat-inactivated cells) twice daily, for 14–28 days
Available Forms
Researched For
Clinical Evidence
A Targeted Probiotic That Binds to H. Pylori Bacteria: Lactobacillus reuteri DSM 17648
Deep inside your stomach lives a tenacious little troublemaker called Helicobacter pylori — a spiral-shaped bacterium that clings to the stomach lining and can cause everything from persistent bloating and indigestion to peptic ulcers and, in some cases, contribute to stomach cancer risk over many years. Lactobacillus reuteri DSM 17648 is a very special strain developed specifically with this enemy in mind. What makes it extraordinary is its mechanism: instead of simply competing for space or producing generic antimicrobial compounds like most probiotics do, this strain physically co-aggregates with H. pylori — think of it like a molecular handshake that won't let go. Once they're bound together, the harmful bacteria can no longer grip the stomach wall and are swept out of the body naturally. It's like sending in a highly trained decoy that tricks H. pylori into hitching a ride straight out of the system.
For the millions of people dealing with the misery of an H. pylori infection — the burning stomach pain after meals, the relentless nausea, the bloating that makes it hard to enjoy food — this strain offers something genuinely exciting. In clinical research, people who used this strain alongside their prescribed antibiotic treatment reported dramatically better outcomes. Their H. pylori eradication rates were significantly higher compared to those who only took antibiotics. But perhaps just as importantly, they felt better during treatment. The stomach cramps, constipation, and general digestive discomfort that so often come with antibiotic therapy were noticeably reduced. People also reported fewer headaches — a common complaint during standard H. pylori treatment regimens. Beyond active infection, there is also growing interest in this strain's role in managing halitosis (chronic bad breath), since H. pylori colonisation in the stomach and oral cavity is known to be a contributing factor. By helping to reduce the bacterial load, this strain may support fresher breath from the inside out.
One of the most interesting things about Lactobacillus reuteri DSM 17648 is that it is typically used as a postbiotic — meaning the bacterial cells are heat-inactivated before you take them. This is actually a feature, not a bug. Because the cells are non-viable, there is no risk of the bacteria colonising the gut in ways that are hard to predict, and the product is inherently more shelf-stable. Safety data from multiple clinical trials confirm an excellent tolerability profile, with no serious adverse effects reported. It is generally taken as a supplement alongside, or immediately following, standard antibiotic eradication therapy. The typical protocol runs for two to four weeks, often at a dose of around 200 mg twice daily. While this strain is primarily studied in adults, emerging postbiotic research is beginning to explore its potential across a broader range of gastrointestinal conditions. As always, anyone dealing with a confirmed H. pylori infection should work with their doctor to determine the right treatment plan — this strain is best viewed as a powerful adjunct to medical care, not a standalone cure.
Common Questions
Frequently Asked Questions
Sources
Scientific References
Curated By

Clara Hayes
Lead Research Editor
Clara leads the curation and verification of microbiome research for our platform. With extensive experience in translating complex scientific literature into accessible insights, she ensures every strain profile is grounded in peer-reviewed evidence and contextual accuracy.
Medical Disclaimer
The information provided on probioticstrains.com is intended for educational and informational purposes only. It does not constitute medical advice, diagnosis, or treatment. Strain profiles and clinical summaries are compiled from published peer-reviewed literature. While we may evaluate or highlight specific commercial formulations, our insights are always grounded in available scientific evidence. Always consult a qualified healthcare provider before starting, changing, or stopping any supplement or health regimen.